Eli Lilly and Company

Quotes on the micro-cap drugmaker Organovo Holdings skyrocketed 244% yesterday, February 25, before gaining another 22% in premarket trading today. This came after the company <a href="https://ir.organovo.com/news-releases/news-release-details/organovos-fxr-program-including-fxr314-be-acquired-eli-lilly-and">announced</a> the sale of its drug development program for inflammatory bowel disease to pharma giant Eli Lilly. Industry news outlet FirstWorld Pharma <a href="https://firstwordpharma.com/story/5937660">believes</a> that for Organovo, which has almost $350 million in debt, the deal serves as a “lifeline,” while it presents Eli Lilly with an opportunity to strengthen its position in metabolic disorder therapies.

Biotech small cap Organovo soars 244% as giant Eli Lilly buys its IBD drug program

BioStem Technologies, Inc.

Zacks Small-Cap Research (Zacks SCR) <a href="https://scr.zacks.com/news/news-details/2025/BSEM-Continues-to-Excel/default.aspx">reiterated</a> its recommendation on placenta-based drug maker BioStem Technologies, citing the company’s record top line in the fourth quarter of 2024, combined with a stream of positive news and an expected uplisting of its stock to Nasdaq’s main bourse. Amid <a href="https://finance.yahoo.com/quote/BSEM/">losses</a> of 30% for BioStem in less than three weeks, Zacks SCR sees upside of almost 150% for the stock.

Zacks recommends small-cap drugmaker BioStem that has sunk 30% in three weeks

ProPetro Holding Corp.

Applied Digital Corporation

Freedom Holdings Corp.

Freedom Finance Global has dug up the five small-cap stocks that were most popular among hedge funds at the end of 2024. Three of the companies operate in the IT sector, the most favored with portfolio managers, who allocated more than a quarter of their portfolios to IT names. Another top-five company specializes in fintech, while the last is an oil and gas services firm.

Freedom Holding Corp. analytics names five most popular small-cap holdings

The founder of the small-cap genetic testing company 23andMe has <a href="https://www.sec.gov/Archives/edgar/data/1804591/000095017025024862/xslSCHEDULE_13D_X01/primary_doc.xml">offered</a> to buy shareholders out. This is the second attempt in the last year to take 23andMe private. In the summer of 2024, shareholders <a href="https://www.reuters.com/business/healthcare-pharmaceuticals/23andme-cuts-40-its-workforce-2024-11-11/#:~:text=In%20July%2C%20the%20CEO%20and%20co%2Dfounder%20proposed%20to%20acquire%20all%20outstanding%20shares%20of%20the%20firm%20not%20already%20owned%20by%20her%20or%20her%20affiliates%20for%2040%20cents%20each.">were offered</a> a price six times lower than the current one, but even after the publication of the new offer on Friday, February 21, the company’s stock plummeted.

Shares of former unicorn 23andMe plummet following new buyout offer

VNET Group, Inc.

Chinese data center operator VNET Group, whose ADRs trade on the Nasdaq, has <a href="https://finance.yahoo.com/quote/VNET/">soared almost 200%</a> since the start of 2025, <a href="https://www.barrons.com/articles/vnet-stock-price-ai-china-4463693c?mod=RTA">reports</a> <i>Barron’s</i>. Investors are betting the company will benefit from a spending spree on computing power from China’s big tech firms, particularly e-commerce giant Alibaba. At the same time, <i>Barron’s</i> cites the cautionary tale of how Chinese tech stocks have rocketed before, only to tumble in the wake of regulatory crackdowns.

Small-cap data center operator VNET Group in spotlight after near 200% return in 2025

Innodata Inc.

The company’s market value has skyrocketed 670% since the start of the year

Innodata surges to fresh record after strong earnings

Acurx Pharmaceuticals, Inc.

Acurx Pharmaceuticals, a drugmaker developing new types of antibiotics, aims to combat the growing issue of antimicrobial resistance. It has a market capitalization of just $13.3 million, but analysts <a href="https://www.marketwatch.com/investing/stock/acxp/analystestimates?mod=mw_quote_tab">see</a> massive upside for the stock.

Why antimicrobial drug developer Acurx has 1,500% upside

DDC Enterprise Limited

Quotes on micro-cap ready-made meal maker DayDayCook (DDC) <a href="https://www.marketwatch.com/investing/stock/ddc">jumped</a> 25% yesterday, February 19, after the company <a href="https://ir.stockpr.com/daydaycook/sec-filings-email/content/0001213900-25-015078/ea0231393-6k_ddcenter.htm">shared</a> two updates with investors. First, in 2024, its revenue grew at least 17.6% on preliminary numbers. Second, it unveiled a proposal to shareholders regarding overdue loan payments.

Asian food maker DayDayCook soars amid negotiations with creditors

TruGolf Holdings, Inc.

Shares of TruGolf Holdings, a micro-cap supplier of indoor golf simulators that allow people to play at home or in enclosed stadiums, <a href="https://www.marketwatch.com/investing/stock/trug">surged</a> more than 25% yesterday, February 19. The company <a href="https://app.quotemedia.com/data/downloadFiling?webmasterId=104761&amp;ref=318930108&amp;type=HTML">reported</a> record revenue for 2024, and its second-half EBITDA is expected to exceed even the boldest forecasts by nearly 50%.

Golf simulator TruGolf soars on upbeat preliminary results

Comstock Inc.

Shares of Comstock, a small-cap provider of decarbonization solutions, <a href="https://finance.yahoo.com/quote/LODE/">fell</a> more than 10% yesterday, February 18, and continued to retreat as of this writing today, February 19. The trigger was an <a href="https://comstock.inc/press-release/comstock-announces-reverse-stock-split/">announced</a> reverse stock split whereby 10 shares will be consolidated into one. Still, the authorized number of shares will remain unchanged, meaning that if the company needs to raise capital, it will be able to sell more shares, according to Noble Capital Markets.

Eco-tech small cap Comstock dives after reverse stock split

Enovis Corporation

Quaker Chemical Corporation

Kadant Inc.

Managers of the Royce Premier Fund have <a href="https://www.royceinvest.com/insights/2025/1Q25/4-small-cap-premier-holdings">revealed</a> which holdings contributed and detracted the most from the portfolio’s performance in 2024. The Royce Premier Fund, like all funds offered by the firm founded by <a href="https://oninvest.com/article/kak-investirovat-v-small-cap-pat-covetov-ot-caka-rojsa-legendy-uoll-strit">Wall Street legend</a> Chuck Royce, invests in small-cap stocks, but it <a href="https://www.royceinvest.com/funds/royce-premier-fund/ryprx">specializes</a> in “premier” assets, capable of generating excess cash flow and reinvesting it to grow.

Royce Premier Fund reveals biggest contributing and detracting holdings of 2024

Berkshire Hathaway Inc.

Pershing Square Holdings Ord

The prominent Wall Street activist investor looks to follow in Warren Buffett’s footsteps.

Small caps